Plasma MicroRNA-21 Is Associated with Tumor Burden in Cutaneous Melanoma
نویسندگان
چکیده
منابع مشابه
Prognostic significance of microscopic tumor burden in sentinel lymph node in patients with cutaneous melanoma.
BACKGROUND/AIM Sentinel lymph node (SLN) biopsy provides useful prognostic information for patients with melanoma. The present study sought to determine the prognostic value of SLN tumor burden on overall survival (OS) and disease-free survival (DFS). We also assessed its association with non-sentinel lympth node (NSLN) involvement. PATIENTS AND METHODS We conducted a retrospective review of ...
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BACKGROUND MiR-126 is frequently downregulated in a variety of malignancies and acts as a potential tumor suppressor. It also played a tumor suppressor role in human melanoma through the direct or indirect repression of several key oncogenic molecules. METHODS qRT-PCR assay was performed to examine the expression of miR-126. Associations between miR-126 expression and various clinicopathologi...
متن کاملDiffuse Cutaneous Melanosis Associated with Malignant Melanoma.
780 Ann Dermatol Received December 10, 2014, Revised February 7, 2015, Accepted for publication February 18, 2015 Corresponding author: Joanna Mangana, Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, CH 8091, Zurich, Switzerland. Tel: 41-44-255-3155, Fax: 41-44-255-454, E-mail: johanna. mangana@ usz.ch This is an Open Access article distributed under the terms of the Cr...
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BACKGROUND Although numerous studies have reported altered plasma levels of various microRNAs (miRNAs) in patients with cardiovascular disease, there are no data on the relationship between plasma miRNAs and vulnerable coronary plaque. In this study, we investigated whether plasma miRNAs might be a sensitive marker of coronary plaque vulnerability. METHODS AND RESULTS Integrated backscatter i...
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An effective circulating tumour marker is needed for melanoma especially with the advent of targeted therapies. Gene expression studies examining primary melanomas have shown that increased expression of osteopontin (SPP1) is associated with poor prognosis. Studies subsequently reported higher blood levels in melanoma patients with metastatic disease than those without. This study was designed ...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2013
ISSN: 0022-202X
DOI: 10.1038/jid.2012.477